Synthesis and Antimicrobial Activity of Pyrazolone- Thioxopyrimidone Clubbed Heterocyclic Compounds

Published in Journal

Anusandhan (RNTUJ-AN) [RNTUJ-AN] (Vol:17/ Issue: 26) DOI: [NA]
Authors: Nikulsinh Sarvaiya1 Sheetal Gulati2 H. S. Patel3
Subjects: Science Technology and Management

Year: March.2021
Volume: 17 / Issue: 26
Pages: 2388-2392
Publisher: ANUSANDHAN(RNTUJ-AN)
Source:
ISSN: 2278-4187
E-ISSN: 2457-0656
DOI: NA
Published URL:
Published On: March.2021

Article Details

Synthesis and Antimicrobial Activity of Pyrazolone- Thioxopyrimidone Clubbed Heterocyclic Compounds | Original Article

Nikulsinh Sarvaiya1 Sheetal Gulati2 H. S. Patel3 in Anusandhan (RNTUJ-AN) | Multidisciplinary Academic Research

ABSTRACT:

ABSTRACT

Ethyl 3-oxo-2-(2-(4-(N-thiazol-2-ylsulfamoyl) phenyl) hydrazono)butanoate (1) on condensation with 4-(4-alkyl phenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro pyrimidine-5- carbohydrazide (2a-e) to afford 2-(1-(4-(4-alkyl phenyl)-6-methyl-2-thioxo-1,2,3,4- tetrahydro pyrimidine-5-carbonyl) -3-methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-N-(thiazol-2- yl) hydrazine sulfonamide (3a-e). On reaction (3a-e) with 1,2-dibromoethane yield 2-(1-(7-

(4-alkyl phenyl)-5-methyl-3,7,8,8a-tetrahydro-2H-thiazolo[3,2-a]pyrimidine-6-carbonyl)-3- methyl-5-oxo-1H-pyrazol-4(5H)-ylidene)-N-(thiazol-2-yl)hydrazinesulfonamide(4a-e).The structures of all the compounds series (3a-e) and (4a-e) were characterized analytically. The compounds were also monitored for anti microbial activity.